Publications
2022
Prediction of Response to Cisplatin-Based Neoadjuvant Chemotherapy of Muscle-Invasive Bladder Cancer Patients by Molecular Subtyping including KRT and FGFR Target Gene Assessment. Int J Mol Sci. 2022 Jul 18;23(14):7898.
2022
Membranous NECTIN-4 expression frequently decreases during metastatic spread of urothelial carcinoma and is associated with enfortumab vedotin resistance. Clin Cancer Res. 2022 Dec 19:CCR-22-1764.
2022
2022
2022
Comparative evaluation of somatostatin and CXCR4 receptor expression in different types of thyroid carcinoma using well-characterised monoclonal antibodies.BMC Cancer. 2022 Jul 7;22(1):740.
2022
2021
2021
2021
2021
2021
2021
2021
2021
2021
2021
2020
2020
FOXA1 Gene Expression for Defining Molecular Subtypes of Muscle-Invasive Bladder Cancer after Radical Cystectomy. J Clin Med. 2020 Apr 2;9(4):994. doi: 10.3390/jcm9040994.
Cancers (Basel). 2020 Sep 29;12(10):2794. doi: 10.3390/cancers12102794. PMID: 33003392 Analysis of CXCL9, PD1 and PD-L1 mRNA in Stage T1 Non-Muscle Invasive Bladder Cancer and Their Association with Prognosis.
Cytotoxic T-cell-related gene expression signature predicts improved survival in muscle-invasive urothelial bladder cancer patients after radical cystectomy and adjuvant chemotherapy. J Immunother Cancer. 2020 May;8(1):e000162. doi: 10.1136/jitc-2019-000162. PMID: 32448798
2020
Rinaldetti S, The Role of CXCL13 and CXCL9 in Early Breast Cancer. Clin Breast Cancer. 2020 Feb;20(1):e36-e53. doi: 10.1016/j.clbc.2019.08.008. Epub 2019 Sep 5. PMID: 31699671
2020
JCO Precis Oncol. 2020 Jul 24;4:PO.19.00337. doi: 10.1200/PO.19.00337. eCollection 2020. PMID: 32923902 Frequent Molecular Subtype Switching and Gene Expression Alterations in Lung and Pleural Metastasis From Luminal A-Type Breast Cancer.
2020
Diagnostics (Basel). 2020 Jun 4;10(6):369. doi: 10.3390/diagnostics10060369. PMID: 32512707 Impact of mRNA-Assessed Molecular Subtype Conversion, Intact and Apoptotic Circulating Tumor Cells on Survival of Metastatic Breast Cancer Patients: Proof of Principle.
2019
2019
Cancers (Basel). 2019 Mar 11;11(3):342. doi: 10.3390/cancers11030342. PMID: 30862027 Molecular Subtype Conversion between Primary and Metastatic Breast Cancer Corresponding to the Dynamics of Apoptotic and Intact Circulating Tumor Cells.
2019
BMC Cancer. 2019 Jul 15;19(1):694. doi: 10.1186/s12885-019-5890-z. PMID: 31307414 Impact of molecular subtypes on the prediction of distant recurrence in estrogen receptor (ER) positive, human epidermal growth factor receptor 2 (HER2) negative breast cancer upon five years of endocrine therapy.
2019
FOXM1 overexpression is associated with adverse outcome and predicts response to intravesical instillation therapy in stage pT1 non-muscle-invasive bladder cancer. BJU Int. 2019 Jan;123(1):187-196. doi: 10.1111/bju.14525. Epub 2018 Sep 9. PMID: 30120861
2019
Br J Cancer. 2019 Dec;121(12):1009-1015. doi: 10.1038/s41416-019-0630-3. Epub 2019 Nov 15. PMID: 31728025
2019
European Patent in Immunoncology: From Immunological Principles of Implantation to Cancer Treatment. Int J Mol Sci. 2019 Apr 12;20(8):1830. doi: 10.3390/ijms20081830. PMID: 31013867
2019
Transl Oncol. 2019 Apr;12(4):661-668. doi: 10.1016/j.tranon.2019.01.005. Epub 2019 Mar 2. PMID: 30831560 Androgen Receptor mRNA Expression in Urothelial Carcinoma of the Bladder: A Retrospective Analysis of Two Independent Cohorts.
2018
Rinaldetti S, Wirtz R, Worst TS, Hartmann A, Breyer J, Dyrskjot L, Erben P. FOXM1 predicts disease progression in non-muscle invasive bladder cancer. J Cancer Res Clin Oncol. 2018 Sep;144(9):1701-1709. doi: 10.1007/s00432-018-2694-5. Epub 2018 Jun 29.
2018
Virchows Arch. 2019 Feb;474(2):209-217. doi: 10.1007/s00428-018-2496-9. Epub 2018 Nov 27. PMID: 30483954 Analysis of the prognostic relevance of sex-steroid hormonal receptor mRNA expression in muscle-invasive urothelial carcinoma of the urinary bladder
2018
Int J Mol Sci. 2018 Oct 30;19(11):3396. doi: 10.3390/ijms19113396. PMID: 3038073 mRNA-Expression of KRT5 and KRT20 Defines Distinct Prognostic Subgroups of Muscle-Invasive Urothelial Bladder Cancer Correlating with Histological Variants.
2018
2018
Urol Oncol. 2018 Dec;36(12):530.e19-530.e27. doi: 10.1016/j.urolonc.2018.09.003. Epub 2018 Nov 13. PMID: 30446441 Predictive value of lymphangiogenesis and proliferation markers on mRNA level in urothelial carcinoma of the bladder after radical cystectomy.
2018
Transl Oncol. 2018 Apr;11(2):467-476. doi: 10.1016/j.tranon.2018.02.001. Epub 2018 Feb 23. PMID: 29477637 Prognostic Value of Molecular Breast Cancer Subtypes based on Her2, ESR1, PGR and Ki67 mRNA-Expression in Muscle Invasive Bladder Cancer.
2018
2018
Sci Rep. 2018 Sep 26;8(1):14383. doi: 10.1038/s41598-018-32569-x. PMID: 30258198 CDKN2A as transcriptomic marker for muscle-invasive bladder cancer risk stratification and therapy decision-making.
2018
2018
2018
Virchows Arch. 2016 Nov;469(5):547-552. doi: 10.1007/s00428-016-2002-1. Epub 2016 Aug 11. PMID: 27514658 ESR1, ERBB2, and Ki67 mRNA expression predicts stage and grade of non-muscle-invasive bladder carcinoma (NMIBC).
2018
2018
2018
2018
2018
Evaluation of the prognostic value of CD3, CD8, and FOXP3 mRNA expression in early-stage breast cancer patients treated with anthracycline-based adjuvant chemotherapy. Cancer Med. 2018 Oct;7(10):5066-5082. doi: 10.1002/cam4.1730. Epub 2018 Sep 21. PMID: 30240146
2017
2017
2017
2017
2017
2017
Stefanovic S, Wirtz RM, Deutsch TM, Hartkopf A, Sinn P, Varga Z, Sobottka B, Sotiris L, Taran FA, DomschkeC, HennigsA, Brucker SY, Sohn C, Schuetz F, Schneeweiss A, Wallwiener M. Tumor biomarker conversion between primary and metastatic breast cancer: mRNA assessment and its concordance with immunohistochemistry. Oncotarget, Advance Publications 2017
2017
Rinaldetti S, Wirtz RM, Worst TS, Eckstein M, Weiss CA, Breyer J, Otto W, Bolenz C, Hartmann A, Erben P. FOXM1 predicts overall and disease specific survival in muscle-invasive urothelial carcinoma and presents a differential expression between bladder cancer subtypes. Oncotarget. 2017 Apr 24. doi: 10.18632/oncotarget.17394. [Epub ahead of print]
2017
2017
Brückl WM, Wirtz RM, Bertsch T, Ficker JH, Jung A. [Liquid Biopsy: Detection of Molecular Markers for Treatment Decisions in Lung Cancer]. Pneumologie. 2017 Mar;71(3):151-163. doi: 10.1055/s-0042-123803. Epub 2017 Feb 14. Review. German.
2017
2017
2017
Breyer J, Wirtz RM, Otto W, Erben P, Kriegmair MC, Stoehr R, Eckstein M, Eidt S, Denzinger S, Burger M, Hartmann A; on behalf of the BRIDGE Consortium. In stage pT1 non-muscle-invasive bladder cancer (NMIBC), high KRT20 and low KRT5 mRNA expression identify the luminal subtype and predict recurrence and survival. Virchows Arch. 2017 Jan 10. doi: 10.1007/s00428-017-2064-8
2016
2016
Kriegmair MC, Balk M, Wirtz R, Steidler A, Weis CA, Breyer J, Hartmann A, Bolenz C, Erben P. Expression of the p53 Inhibitors MDM2 and MDM4 as Outcome Predictor in Muscle-invasive Bladder Cancer.. Anticancer Res. 2016 Oct;36(10):5205-5213.
2016
2016
2016
2016
2016
2016
2015
2015
2015
2015
2015
2015
2015
2015
2015
2015
2014
2014
2014
2014
2013
2013
2013
2013
2013
2013
2013
2013
2012
2012
2012
2012
2012
2012
2012
Sinn HP, Keller M, Waldburger N, Schneeweiss A, Wirtz R. Evaluation of tumor proliferation and hormone receptor status in breast cancer. Comparison of quantitative real time PCR, Image analysis of IHC, and visual scoring. Jahrestagung der Deutschen Gesellschaft für Pathologie 2012; SO-024.
2012
Wirtz RM, Bertz S, Keck B,Claas S, Dyrskjot L, Orntoft T, Wullich B, Hake R, Eidt S, Hartmann A. Prognostic role of androgen receptor in bladder cancer. Jahrestagung der Deutschen Gesellschaft für Pathologie 2012; SO-067.
2012
Knaup S, Wach S, Agalmy A, Schulze-Luehmann J, Hugele M, Chaklam S, Atreya R, Wirtz R, Tau TT, Schneider-Stock R. miRNA 26b stabilizes the pro-apoptotic DAP Kinase by inhibiting its E3 ubiquitine ligase DIP1.Jahrestagung der Deutschen Gesellschaft für Pathologie 2012; DO-115.
2012
2012
2012
2012
2012
2011
Wirtz R, Leinonen M, Bono P, Isola J, Kellokumpu-Lehtinen PL, Kataja V, Turpeeniemi-Hujanen T, Jyrkkiö S, Huang W, Eidt S, Joensuu H. RACGAP1 mRNA assay outperforms Ki-67 as a proliferation marker in the FinHer study cohort. P02-12-04. SABCS 2011.
2011
Huang W, Wirtz R, Weidler J, Lie Y, Sherwood T, Leinonen M, Bono P, Isola J, Kellokumpu-Lehtinen PL, Joensuu H. Quantitative measurements of HER2 protein expression and HER2 mRNA expression as continous variable in breast cancer of he FinHer study. P01-07-01. SABCS 2011.
2011
Wirtz R, Eidt S. Quantitative Bestimmung tumorinfiltrierender Lymphozyten mittels qRT-PCR in formalinfixierten Tumorgeweben zur Prädiktion von Brustkrebs – Immune STRATIFYER. Jahrestagung der Deutschen Gesellschaft für Senologie 2011.
2011
Wirtz R, Leinonen M, Eidt S, Joensuu H. Überlegenheit der molekularpathologischen Proliferatonsmessung gegenüber Ki67 Bestimmung zur Risikobeurteilung – Proliferation STRATIFYER. Jahrestagung der Deutschen Gesellschaft für Senologie 2011.
2011
Wirtz R, Riehm K, Hellmich M, Gevensleben H, Sinn P, Eidt S, Schmutzler R. BRCA1 Defizienztestung in triple negativen, luminalen und BRCA1 positiven Tumoren. Jahrestagung der Deutschen Gesellschaft für Senologie 2011.
2011
Wirtz R, Brueckl WM, Eschbach C, Wiest GH, Ficker JH, Zirlik S, Hake R, Eidt S, Hartmann A. Prognostische Bedeutung von ESR1, PGR und SNAIL2 mRNA Expression beim Nicht-kleinzelligen Bronchialkarzinom. Jahrestagung der Deutschen Gesellschaft für Pathologie 2011.
2011
Brueckl WM, Eschbach C, Wiest GH, Ficker JH, Zirlik S, Hake R, Eidt S, Hartmann A, Wirtz RM. Influence of expression of estrogen (ESR1) and progesterone (PGR) receptors on metastatic spread and outcome in non-small cell lung cancer (NSCLC). J Clin Oncol 29: 2011 (suppl: abstr 7585)
2011
Fountzilas E, Angouridakis N, Karasmanis I, Wirtz RM, Eleftheraki AG, Veltrup E, Markou K, Nikolaou A, Konstantinopoulos P, Kotoula V, Fountzilas G. Prediction of clinical outcome in patients with primary laryngeal carcinoma using gene expression profiling. J Clin Oncol 29: 2011 (suppl: abstr 5505)
2011
2011
2011
2010
2010
2010
2010
Croner RS, Wirtz R, Lausen B, Prokosch HU, Rödel C, Rödel F, Naschberger E, Wein A, Brückl WM, Hartmann A, Hohenberger W, Stürzl M – Prospective evaluation of predictive and prognostic molecular markers in colorectal carcinomas. J Clin Oncol 28, 2010 (suppl; abstr e14114)
2010
Atmaca A, Steinmetz K, Pauligk C, Wirtz R, Homann N, Hofheinz R, Petry C, Altmannsberger HM, Jäger E, Al-Batran S – Validation of tumoral matrix-metalloproteinase-9 (MMP-9) mRNA expression as a molecular prognostic factor for metastatic gastroesophageal cancer . J Clin Oncol 28:15s, 2010 (suppl; abstr 4017)
2010
Psyrri D, Kronenwett R, Timotheadou E, Wirtz RM, Onyenadum A, Pentheroudakis GE, Papadimitriou CA, Razis E, Economopoulos T, Fountzilas G – Evaluation of the prognostic value of ube2c mrna levels in early breast cancer. J Clin Oncol 28:15s, 2010 (suppl; abstr 10570)
2009
2009
Pentheroudakis G, Kostadima L, Dova L, Georgiou I, Tzavaras T, Vartholomatos G, Wirtz RM, Fountzilas G, Malamou-Mitsi V, Pavlidis N – A twisted kiss: in vitro and in vivo evidence of genetic variation and suppressed transcription of the metastasis-suppressor gene KiSS1 in early breast cancer – Neoplasma. 2010;57(1):47-54.
2009
2009
2009
Pentheroudakis G, Angouridakis N, Wirtz R, Nikolaou A, Kalogeras KT, Pavlidis N, Fountzilas G – Transcriptional Activity of Human Epidermal Growth Factor Receptor Family and Angiogenesis Effectors in Locoregionally Recurrent Head and Neck Squamous Cell Carcinoma and Correlation with Patient Outcome – J Oncol. 2009;2009:854127. Epub 2009 Oct 7.
2009
Schröder C, Schumacher U, Fogel M, Feuerhake F, Müller V, Wirtz RM, Altevogt P, Krenkel S, Jännike F, Milde-Langosch K – Expression and prognostic value of L1-CAM in breast cancer. Oncology Reports 22: 1109-1117, 2009
2009
Zamagni C, Wirtz RM, De Iaco P, Veltrup E, Sehouli J, Dietel M, Rosati M, Denkert C, Martoni A – Estrogen receptor 1 mRNA predicts survival after neoadjuvant chemotherapy in ovarian cancer – determination by array and kinetic PCR in fresh tissue biopsies. Endocrine Relat Cancer 2009 Sep 11. [Epub ahead of print]
2009
Darb-Esfahani S, Wirtz RM, Sinn B, Budczies J, Noske A, Weichert W, Faggad A, Scharff S, Sehouli J, Oskay-Özcelik G, Martoni A, De Iaco P, Dietel M, Zamagni C, Denkert C – Estrogen receptor 1 mRNA is a prognostic factor in ovarian carcinoma – determination by kinetic PCR in formalin fixed tissue. Endocrine Relat Cancer 2009 Aug 12. [Epub ahead of print]
2009
Noske A, Faggad A, Wirtz R, Darb-Esfahani S, Sehouli J, Sinn B, Nielsen FC, Weichert W, Buckendahl AC, Röske A, Müller B, Dietel M, Denkert C – IMP3 expression in human ovarian cancer is associated with improved survival. Int J Gynecol Pathol. 2009 May;28(3):203-10.
2009
Faggad A, Darb-Esfahani S, Wirtz R, Sinn B, Sehouli J, Könsgen D, Lage H, Noske A, Weichert W, Buckendahl AC, Budczies J, Müller BM, Elwali NE, Dietel M, Denkert C – Expression of multidrug resistance-associated protein 1 in invasive ovarian carcinoma: implication for prognosis. Histopathology. 2009 May;54(6):657-66.
2009
Papaxoinis G, Pectasides D, Wirtz RM, Kotoula V, Papadimitriou C, Gogas H, Aravantinos G, Skarlos D, Kalogeras KT, Fountzilas G – Prognostic significance of PI3K mRNA expression in patients with operable high-risk breast cancer- J Clin Oncol 27:15s, 2009 (suppl; abstr 577)
2009
Pauligk C, Wirtz R, Steinmetz K, Hartmann JT, Homann N, Hofheinz RD, Petry C, Altmannsberger HM, Jäger E, Al-Batran S – Matrix metalloproteinase-9 (MMP-9) and vascular endothelial growth factor (VEGF) mRNA expression in patients with metastatic gastric cancer receiving first-line chemotherapy – J Clin Oncol 27:15s, 2009 (suppl; abstr 4547)
2009
Kronenwett R, Stropp U, Briasoulis E, Gehrmann M, Razis E, Hennig G, Bafaloukos D, Wirtz RM, Economopoulos T, Fountzilas G – Utility of a multigene prognostic algorithm in combination with TP53 expression for prediction of benefit from adjuvant taxane-containing chemotherapy in node-positive breast cancer patients – J Clin Oncol 27:15s, 2009 (suppl; abstr 593)
2009
Wirtz RM – Die Krux mit der Bestimmung des Hormonrezeptors – Problems when determining the hormone receptor status – mammazoneMAG May 2009
2009
Faggad A, Darb-Esfahani S, Wirtz R, Sinn B, Sehouli J, Könsgen D, Lage H, Weichert W, Noske A, Budczies J, Müller BM, Buckendahl AC, Röske A, Eldin Elwali N, Dietel M, Denkert C. Topoisomerase II alpha mRNA and protein expression in ovarian carcinoma: correlation with clinicopathological factors and prognosis. Mod Pathol. 2009 Apr;22(4):579-88. Epub 2009 Mar 6.
2009
Gentner B, Wein A, Croner RS, Zeittraeger I, Wirtz RM, Roedel F, Dimmler A, Dorlaque L, Hohenberger W, Hahn EG, Brueckl WM — Differences in the gene expression profile of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) in primary colorectal cancers and their synchronous liver metastases – Anticancer Res 2009Jan; 29(1):67-74.
2008
Papadimitriou CA, Kalogeras KT, Wirtz RM, Briasoulis E, Hennig G, Vourli G, Stropp U, Gogas H, Galani E, Samantas E, Makatsoris T, Fountzilas G – ] Elevated mRNA expression of herstatin predicts poor outcome in patients with high-risk early breast cancer. A possible molecular predictor of treatment benefit in the context of a Hellenic cooperative oncology group trial. SABCS 2008 #6066
2008
Kronenwett R, Kalogeras KT, Stropp U, Weber K, Dafni U, Gehrmann M, Pectasides D, von Toerne C, Papakostas P, Wirtz RM, Fountzilas G – [6044] Prognostic algorithm identified in node-negative early breast cancer patients predicts outcome also in node-positive patients treated with adjuvant chemotherapy. SABCS 2008 #6044
2008
Ihnen M, Müller V, Wirtz RM, Milde-Langosch K, Witzel I, Lisboa BW, Jänicke F – Prediction of chemotherapy response in breast cancer by using a four-gene panel including osteopontin, activating leukocyte cell adhesion molecule (ALCAM), HER2 and estrogen receptor (ER). SABCS 2008 #2033
2008
Loibl S, Müller B, Roller M, Kronenwett R, Darb-Esfahani S, Komor M, von Toerne C, Wirtz R, von Minckwitz G, Denkert C – Local versus central HER2 immunohistochemistry correlates with kinetic RT-PCR but only central immunohistochemistry and RT-PCR predict pathological complete response: results from the neoadjuvant multicenter GeparTrio trial. SABCS 2008 #1070
2008
Koutras AK, Kalogeras KT, Dimopoulos MA, Wirtz RM, Dafni U, Briasoulis E, Pectasides D, Gogas H, Christodoulou C, Aravantinos G, Zografos G, Timotheadou E, Papakostas P, Linardou H, Razis E, Economopoulos T, Kalofonos HP, Fountzilas G – Evaluation of the prognostic and predictive value of HER family mRNA expression in high-risk early breast cancer: a Hellenic Cooperative Oncology Group (HeCOG) study. Br J Cancer. 2008 Dec 2;99(11):1775-85. Epub 2008 Nov 4.
2008
Al-Batran S, Pauligk C, Wirtz R, Steinmetz K, Probst S, Hartmann JT, Hofheinz R, Homann N, Altmannsberger HM, Petry C, Jäger E – The expression of the epidermal growth factor receptor (EGFR) and related molecules and their impact on survival in patients with metastatic gastric cancer receiving first-line chemotherapy: Results from the FLO versus FLP gastric cancer phase III trial of the AIO. Gastrointestinal Cancer Symposium 2008
2008
Pentheroudakis G, Kalogeras KT, Wirtz RM, Grimani I, Zografos G, Gogas H, Stropp U, Pectasides D, Skarlos D, Hennig G, Samantas E, Bafaloukos D, Papakostas P, Kalofonos HP, Pavlidis N, Fountzilas G. – Gene expression of estrogen receptor, progesterone receptor and microtubule-associated protein Tau in high-risk early breast cancer: a quest for molecular predictors of treatment benefit in the context of a Hellenic Cooperative Oncology Group trial. Breast Cancer Res Treat. 2008 Jul 31. [Epub ahead of print]
2008
Pauligk C, Wirtz RM, Steinmetz K, Probst S, Hartmann JT, Hofheinz R, Homann N, Altmannsberger HM, Petry C, Jäger E, Al-Batran S – The prognostic role of the epidermal growth factor receptor (EGFR) in patients with metastatic gastric cancer receiving first-line chemotherapy: Results from the FLO versus FLP gastric cancer phase III trial of the AIO. J Clin Oncol 26: 2008 (May 20 suppl; abstr 22033)
2008
Fountzilas G, Wirtz RM, Skarlos P, Dafni U, Pectasides D, Briasoulis E, Bafaloukos D, Xanthakis I, Gehrmann M, Kalogeras KT – Molecular classification based on only four genes identifies basal-like subtypes in high-risk breast cancer patients. J Clin Oncol 26: 2008 (May 20 suppl; abstr 11103)
2008
Zamagni C, Wirtz RM, Sinn B, De Iaco P, Darb-Esfahani S, Rosati M, Dietel M, Massari F, Martoni AA, Denkert C – Estrogen receptor 1 mRNA expression as a strong prognostic factor in epithelial ovarian cancer patients treated with chemotherapy in the adjuvant and neoadjuvant setting. J Clin Oncol 26: 2008 (May 20 suppl; abstr 16547)
2008
Papadimitriou C, Wirtz RM, Economopoulos T, Samantas E, Papakostas P, Gogas H, Razis E, Lianos E, Aravantinos G, Fountzilas G – Differential EGFR and VEGFR mRNA expression in two subtypes of basal-like breast cancer identified by molecular classification. J Clin Oncol 26: 2008 (May 20 suppl; abstr 22092)
2008
Al-Batran S, Wirtz RM, Pauligk C, Steinmetz K, Probst S, Hartmann JT, Hofheinz R, Altmannsberger HM, Petry C, Jäger E – Association of elevated matrix metalloproteinase-9 (MMP-9) mRNA expression levels with resistance to chemotherapy and survival in patients with metastatic gastric cancer receiving first-line chemotherapy: Results from the FLO versus FLP gastric cancer phase III trial of the AIO. J Clin Oncol 26: 2008 (May 20 suppl; abstr 4544)
2008
Brueckl WM, Schoeberl A, Wirtz RM, Murray S, Hahn EG, Wiest GH – Increased vascular-endothelial growth factor (VEGF) tumor expression and response to epidermal growth factor receptor (EGF-R) inhibitor erlotinib in non-small cell lung cancer (NSCLC). J Thorac Oncol. 2008 Mar;3(3):314-6.
2008
Ihnen M, Müller V, Wirtz RM, Schröder C, Krenkel S, Witzel I, Lisboa BW, Jänicke F, Milde-Langosch K – Predictive impact of activated leukocyte cell adhesion molecule (ALCAM/CD166) in breast cancer. Breast Cancer Res Treat. 2008 Jan 3; [Epub ahead of print]
2007
Niesporek S, Weichert W, Sinn B, Röske A, Noske A, Buckendahl AC, Wirtz R, Sehouli J, Koensgen D, Dietel M, Denkert C. – NF-kappaB subunit p65/RelA expression in ovarian carcinoma: prognostic impact and link to COX-2 overexpression. Verh Dtsch Ges Pathol. 2007;91:243-9. .
2007
Fountzilas G, Skarlos D, Wirtz RM, Dafni U, Stropp U, Pectasides D, Papakostas P, Markopoulos C, Karapanagiotis K, Polichronis A, Timotheadou E, Grimani I, Samantas E, Kosmidis P, Kalogeras KT – Prognostic value of both HER-2 and VEGF-A mRNA over-expression in primary tumors of high-risk breast cancer patients – SABCS 2007 #6007
2007
Lenhard MS, Wirtz RM, Hasmueller S, Rueckert S, Ditsch N, Ruehl I, Kahlert S, Bauerfeind I, Untch M, on Behalf of the Participating Centers – Relation of intratumoral B-cells and response to neoadjuvant chemotherapy. SABCS 2007 #2110
2007
Rueckert S, Wirtz R, Lenhard M, Hasmueller S, Ditsch N, Ruehl I, Kahlert S, Bauerfeind I, Untch M – Microtubule-associated protein tau is a marker of pathological complete response in Her-2/neu positive neoadjuvant treated breast cancer patients – SABCS 2007 #2016
2007
Wirtz R.M. – Molekularbiologische Ansätze für eine verbesserte Diagnostik und Selektion gezielter Therapieansätze – 27. Jahrestagung der deutschen Gesellschaft für Senologie – Lübeck Juni 2007 (Oral Presentation)
2007
Wirtz RM, Lenhard MS, Rückert S, Hasmüller S, Konecny G, Fasching P, Euting H, S. Claas S, Ditsch N, Rühl I, Bauerfeind I, Untch M – Determination of Her-2/neu status by semi-automated qRT-PCR in core needle biopsy FFPE tissues, correlation with standard IHC / FISH technology and response to neoadjuvant Trastuzumab-containing regimen (TECHNO-Trial) – AACC 2007
2007
Gehrmann M, Wirtz RM , von Törne C, Stropp U, Schmidt M – Concordance between protein and RNA tissue concentration of estrogen receptor alpha (ER) in fresh frozen as well as formalin fixed paraffin embedded breast tumors – AACC 2007
2007
Gehrmann M, Wirtz RM , von Törne C, Stropp U, Schmidt M – Breast cancer prognosis in node negative early breast cancer – AACC 2007
2007
Zamagni C, Wirtz RM, De Iaco P, Altimari A, Roth K, Rosati F, Rosati M, Massari F, Cacciari N, Martoni AA – Response to primary chemotherapy (CHT) in advanced epithelial ovarian cancer (EOC) patients (pts) and molecular characterization of CHT-resistant tumor cell populations: Findings from the Arianna 02 Project. Journal of Clinical Oncology, 2007 ASCO Annual Meeting Proceedings Part I. Vol 25, No. 18S (June 20 Supplement), 2007: 16059
2007
Brueckl WM, Wirtz RM, Croner RS, Boxberger F, Papadopoulos T, Kirchner T, Hahn EG, Hohenberger W, Wein A – Evaluation of Spondin-1 as a predictive marker for palliative 5-FU based chemotherapy in metastatic colorectal cancer – Journal of Clinical Oncology, 2007 ASCO Annual Meeting Proceedings Part I. Vol 25, No. 18S (June 20 Supplement), 2007: 4112.
2007
Briasoulis EC, Papamichael D, Tzachanis D, Christodoulou C, Samantas E, Razis E, Papakostas P, Bakoyiannis C, Wirtz RM, Kalogeras KT; – Predictive value of EGFR mRNA levels assessed by quantitative RT-PCR in primary tumors of patients treated with cetuximab for metastatic colorectal cancer – Journal of Clinical Oncology, 2007 ASCO Annual Meeting Proceedings Part I. Vol 25, No. 18S (June 20 Supplement), 2007: 4121.
2007
Witzel I, Milde-Langosch K, Ihnen M, Lisboa B, Wirtz R, Müller V – Correlation between protein and RNA tissue concentration of biologic relevant factors in breast cancer – TRAFO 2007 #023
2007
Niesporek S., Weichert W., Sinn B., Röske A., Noske A., Buckendahl A.C., Wirtz R.M., Sehouli J., Koensgen D., Dietel M., Denkert C. – NF-κB subunit p65/RelA expression is an independent prognostic factor in human ovarian cancer and is linked to COX-2 overexpression in vivo and in vitro – AACR 2007 #2514
2007
Wirtz R.M. – Biomarker zur Prädiktion der Wirkung zielgerichteter Medikamente – 1. Forschungswerkstatt Onkologie der Bayer HealthCare AG – Köln 01 March 2007 (Oral Presentation and Publication). Der Onkologe 13 (2007), Suppl. 1, Springer Verlag.
2007
Linardou H., Fountzilas G., Wirtz R.M., Malamou-Mitsi V., Stropp U., Aravantinos G., Pectasides D., Gogas H., Grimani I., Koutras A., Dafni U., Hennig G., Skarlos D. and Kalogeras K.T. – Prognostic value of VEGF-A mRNA expression in primary tumors of high-risk breast cancer patients: a Hellenic Cooperative Oncology Group study. TAT 2007 P703.
2006
Lenhard M.S., Wirtz R.M., Rückert S., Hasmüller S., Ditsch N., Rühl I., Bauerfeind I., Untch M. – Correlation of quantitative Her-2/neu gene expression (TaqMan PCR) with standard immunohistochemistry and fluorescence in situ hybridization in core needle biopsies. SABCS 2006 #4009.
2006
Rueckert S., Wirtz R.M., Lenhard M., Ruehl I., Hasmueller S., Ditsch N., Bauerfeind I., Untch M. – Response prediction in neoadjuvant trastuzumab treated HER-2/neu-positive breast cancer by quantitative RT-PCR analysis of FFPE tissue. SABCS 2006 #3042.
2006
Ruehl I.M., Wirtz R.M., Lenhard M., Hasmueller S., Rueckert S., Ditsch N., Kahlert, Bauerfeind I., Untch M. – Significance of cyclin D1 expression and amplification status in paraffin-embedded tissue of Her2/neu positive breast cancer patients treated in a neoadjuvant trastuzumab-containing protocol (TECHNO-trial). SABCS 2006 #3027.
2006
Fountzilas G., Wirtz R.M., Skarlos D.V., Stropp U., Dafni U., Briasoulis E., Pectasides D., Gogas H., Kalofonos H.P., Papakostas P., Bafaloukos D., Economopoulos T., Aravantinos G., Kalogeras K.T., Dimopoulos M.A. – Prognostic value of DNA and RNA expression of HER-2 compared to that of HER-2 protein levels in primary tumors of high-risk breast cancer patients. SABCS 2006 #2032.
2006
Hasmueller S., Wirtz R.M., Lenhard M., Ditsch N., Rueckert S., Ruehl I., Bauerfeind I. and Untch M. – Amplification of Her2/neu and transcription levels of Her2/neu mRNA measured by RT-PCR in paraffin-embedded core-needle biopsies as predictive markers for response to neoadjuvant therapy with trastuzumab, epirubicin, cyclophosphamide and paclitaxel in early breast cancer (TECHNO-Trial). SABCS 2006 #1042.
2006
Wirtz R.M. – New Perspectives in the characterization and in the monitoring of ovarian cancer patients – Therapeutic Progresses and Perspectives in Ovarian Cancer – Bologna 01 Dec 2006 (Oral Presentation)
2006
Wirtz R.M. – Genetic alterations predicting the response of high-risk breast cancer patients to paclitaxel-based adjuvant chemotherapy – Breast Cancer: From Gene to Therapy – Thessaloniki 18 Nov 2006 (Oral Presentation)
2006
Kostadima L., Pentheroudakis G., Fountzilas G., Dimopoulos M., Pectasides D., Gogas H., Stropp U., Christodoulou C., Samantas E., Wirtz R., Hennig G., Bafaloukos D., Arapantoni P., Kalofonos H., Papakostas P., Economopoulos T., Bamias A., Pavlidis N. -Survivin and glycodelin transcriptional activity in node-positive early breast cancer: mRNA expression of two key regulators of cell survival. Breast Cancer Res Treat 2006; 100(2):161-7.
2006
Brueckl W.M., Wirtz R., Croner R.S., Boxberger F., Schuppert A., Meyer T., Papadopoulos T., Hahn E.G., Hohenberger W., Wein A. – Microarray based response prediction to palliative chemotherapy in metastatic colorectal carcinoma – HOX and MMP gene family members seem to be promising candidates. ESMO 2006 #860P.
2006
Brueckl W.M., Wirtz R., Croner R.S., Boxberger F., Gentner B., Munnes M., Schuppert A., Meyer T., Papadopoulos T., Hahn E.G., Hohenberger W., Wein A. – Hox- and MMP- gene family members are expressed in freshly frozen and paraffin embedded metastatic colorectal carcinoma – implication for response prediction to a palliative 5-FU containing chemotherapy. DKK 2006.
2006
Fountzilas G., Angouridakis N., Wirtz R.M., Claas S., Nikolaou A., Kalogeras K.T. – Prognostic value of VEGFC, HER2 and HER3 gene expression in recurrent squamous cell head and neck tumors -Journal of Clinical Oncology, 2006 ASCO Annual Meeting Proceedings Part I. Vol 24, No. 18S (June 20 Supplement), 2006: 5538.
2005
Brueckl W. M., Croner R. S., Hohenberger W., Munnes M., Wirtz R., Zeittraeger I., Meyer T., Papadopoulos T., Hahn E. G., Wein A. – Response prediction to a 5-Fluorouracil based first-line palliative chemotherapy for metastatic colorectal cancer by gene expression profiling of liver metastases using DNA microarrays- Journal of Clinical Oncology, 2005 ASCO Annual Meeting Proceedings. Vol 23, No. 16S, Part I of II (June 1 Supplement), 2005: 3558.
2005
Fountzilas G., Stropp U., Razis E., Wirtz R., Skarlos D., Gogas H., Pavlidis N., Kalofonos H. P., Pectasides D., Dimopoulos A. M. – Genetic alterations predicting the response of high risk breast cancer patients to Taxol-based adjuvant chemotherapy- Journal of Clinical Oncology, 2005 ASCO Annual Meeting Proceedings. Vol 23, No. 16S, Part I of II (June 1 Supplement), 2005: 9574.
2005
Wirtz R.M. – Molekulare Klassifizierung von Tumoren durch kombinierte DNA/RNA Analyse im Paraffingewebe – 25 th Annual Meeting of the German, Austrian an Suisse Breast Cancer Society – Stuttgart Sep 2005 (Oral Presentation)
2000
Wirtz R., Behrens J. and Birchmeier W. – Interaction of b-catenin with SWI/SNF factors. Keystone Symposia 2000.
1998
Behrens J., Jerchow B-A., Würtele M., Grimm J.,Asbrand C., Wirtz R., Kühl M., Wedlich D. and Birchmeier W. – Functional interaction of an axin homolg, conductin, with b-catenin, APC, and GSK3b. Science 1998; 280: 485-640.
1997
Brix K., Wirtz R. and Herzog V. – Paracrine interation between hepatocytes and macrophages after extrathyroidal proteolysis of thyroglobulin. Hepatology 1997; 26: 1232-1240.